Midway by his profession, Cees Dekker reinvented himself. After several years of hardcore physics, he shifted his concentrate to ‘nanobiology’ within the switch of the millennium. A time period he coined himself, as being a subject of reality.
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Given that 2000, Dekker has shifted the most crucial concentrate of his get the job done in the direction of biophysics the place he studies the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of discipline was pushed by his fascination with the outstanding working of Organic molecular buildings, as well as with the very long-time period perspective that a lot of exciting discoveries is often envisioned During this field.[5] Present traces of investigation in his biophysics team are from the regions of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever analyze in the dynamics DNA supercoils and the invention of supercoil hopping
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
What distinguishes biology from chemistry is that these factors collectively make up a living process. The secret of claimed existence, I do think, lies inside the interactions, the interaction of Individuals molecules. The massive problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from simple molecules in the extremely advanced systems we see nowadays? We do not know. I want to work on These types of big, open thoughts.’
2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore complicated; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
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Bulk-surface area coupling identifies the mechanistic link concerning Min-protein styles in vivo and in vitro
In 1993 he was appointed as Associate Professor at Delft University of Technology. Inside the mid-nineteen nineties Dekker and his team reached achievements with the discovery in the Digital properties of carbon nanotubes, the initial one-molecule transistor as well as other nanoscience.
Lots of new phenomena have been found, and he and his investigate team set up a number one place in this subject of study. Dekker and his investigate group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor dependant on an individual nanotube molecule.
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational modifications in Mre11/DNA repair service complexes; and initial pressure measurements on a DNA molecule in the nanopore
Stable-point out nanopores have demonstrated to generally be a surprisingly versatile probe for one-molecule Assessment of DNA. I'll explain several of our new conclusions – specially DNA knots – together with our initiatives to grow the capabilities of sound-condition nanopores even more, inside the path of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.